Human Growth Peptides Of MGF For Regenerative Capability In
The C-terminal peptide of mechano-growth factor (MGF)
Molecular Formula: C121H200N42O39
Molecular Weight: 2948.15
Appearance: Lyophilized Powder
Place of Origin: China
The C-terminal peptide of mechano-growth factor (MGF), an
alternatively spliced variant of insulin-like growth factor 1
(IGF-1), was found to function independently from the rest of the
molecule and showed a neuroprotective effect in vivo and in vitro.
In vivo, in a gerbil model of transient brain ischemia, treatment
with the synthetic MGF C-terminal peptide provided very significant
protection to the vulnerable neurons. In the same model, ischemia
evoked increased expression of endogenous MGF in the
ischemia-resistant hippocampal neurons, suggesting that the
endogenous MGF might have an important neuroprotective function. In
an in vitro organotypic hippocampal culture model of
neurodegeneration, the synthetic peptide was as potent as the
full-length IGF-1 while its effect lasted significantly longer than
that of recombinant IGF-1. While two peptides showed an additive
effect, the neuroprotective action of the C-terminal MGF was
independent from the IGF-1 receptor, indicating a new mode of
action for this molecule. Although MGF is known for its
regenerative capability in skeletal muscle, our findings
demonstrate for the first time a neuroprotective role against
ischemia for this specific IGF-1 isoform. Therefore, the C-terminal
MGF peptide has a potential to be developed into a therapeutic
modality for the prevention of neuronal damage.
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